when internet people are like “i love gothic literature but i hate anything that discusses incest, sexual violence, oppression, misogyny, abuse, torture, gore, murder, or death”
no actually me and everyone else who’s ever watched crimson peak were brainwashed by guillermo del toro into believing that incest and violence are cool and awesome. sorry
Horrifying that this pearl-clutching over horror actually being dark is unironically becoming A Thing…
The irony of the “umm incest and violence are bad and only evil men would be interested in that 😡” Puritanism being pedaled is that it guarantees that only men get to write about anything taboo and thus dark media is overwhelmingly misogynist.
It’s genuinely sickening how much vile harassment marginalized artists get for making anything darker than Owl House or whatever the Kids Cartoon De Jour is, because these people know how much easier it is to destroy an artist’s life if they’re already marginalized in some way.
Ohh this exactly ^^
Marginalised people (women included btw) are always always held to a much higher standard even in terms of respectability, policed often by members of their own community in a bid to appear more respectable, policed by supposed leftists who don’t want to feel the slightest bit of discomfort to their protected conservative worldview which they never questioned, and at the end of it all privileged men are always going to be the only ones writing any controversial genre fiction because that’s not gonna be a “hard sell” because no one’s coming after them or anything. And so horror remains misogynistic and racist because the moment there’s anything actually horrifying, nuanced, or unsanitized entertained in fiction by a marginalised person there’s an angry horde with pitchforks already gathering at their window for it
just a reminder that people who create fanwork do not owe you anything. writing fanfiction, drawing fanart etc is entirely voluntary and something that should be done for fun!! putting pressure on someone to put out the next chapter of their fic isn’t helping anyone, especially since most fandom creators are students and/or have a job, and also just. have a life. they have friends and family and things to do. and to people who create content, thank you!! you’re appreciated!!
Acetaminophen/paracetamol has a hard stop upper dose limit, above which it becomes extremely toxic.
That limit is 4g (8 “extra strength” (500mg) tablets) in 24 hours (about 2 tablets every 6 hours).
A single dose of 22 extra strength tablets can kill you.
Taking 12 or more tablets per day for more than a week can also kill you (this is about 3 tablets every 6 hours).
Symptoms of overdose take up to 24 hours to manifest, and are fairly difficult to distinguish from other problems. They include abdominal pain (especially right upper quadrant), nausea, malaise, and confusion.
The antidote (n-acetylcystine) must be given within 8hours of ingestion in order to be useful.
After 10 hours the only thing that will work is a liver transplant.
You might think “why would I ever accidentally take so much?”
Well, acetaminophen is in almost everything in the cold/flu/pain aisle. Migraine combos like Excedrin, cold and flu combos like NyQuil, basically anything that says “non-aspirin pain relief”, and anything that’s branded as a fever reducer. It’s all probably acetaminophen/paracetamol.
So the goal of this post is to get you to read the labels on your medications. Because taking taking Tylenol and NyQuil together for a week (like you might if you had the flu) could kill you.
In adults, the minimum toxic dose of acetaminophen as a single ingestion is 7.5 [7,500 mg] to 10 g [10,000 g]; acute ingestion of >150 mg/kg or 12 g [12,000mg] of acetaminophen in adults is considered a toxic dose and carries a high risk of liver damage.
If you have a healthy liver and you just realized that thanks to the cold meds plus the headache meds you’ve taken 4500mg today, you’re probably fine, just don’t do it again tomorrow; on the other hand if you’re looking at something closer to 7500mg, you might want to seek medical advice.
The above source contradicts slightly w/r/t NAC:
In addition, NAC increases local nitric oxide concentrations and promotes microcirculatory blood flow, enhancing local oxygen delivery to peripheral tissues. The microvascular effects of NAC therapy are associated with a decrease in morbidity and mortality, even when NAC is administered in the setting of established hepatotoxicity.5
NAC is maximally hepatoprotective when administered within 8 hours of acute acetaminophen ingestion. When indicated, however, NAC should be administered regardless of the time elapsed since the overdose. Therapy with NAC has been shown to decrease mortality rates in late-presenting patients with hepatic failure, even in the absence of measurable serum APAP levels.6
(The citations are found at original link.)
Essentially NAC is MOST effective when administered within 8 hours, but is likely to decrease mortality rates and morbidity from liver toxicity even if adminstered late, which is useful for those of us with anxiety to know (ie: no, all is not lost if you’re not fast enough).
Sir, r u Okey? I realized that you're 62 years old. . . For me, being 21 is death. You're not going to die yet, are you? I love u so much (even being 40 years younger than you) 🤩
ALT
